RISK OF SEVERE INFECTION ASSOCIATED WITH IMMUNOGLOBULIN DEFICIENCY UNDER RITUXIMAB THERAPY IN IMMUNE-MEDIATED INFLAMMATORY DISEASE

Risk of severe infection associated with immunoglobulin deficiency under rituximab therapy in immune-mediated inflammatory disease

Objectives We evaluated the risk of severe infection in patients with Lotion immune-mediated inflammatory disease (IMID) treated with RTX and with Ig deficiency.Methods This was an observational, retrospective single-centre study of patients undergoing treatment with at least one rituximab (RTX) infusion for an IMID until 31 May 2020.Patients were

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CA1 cell activity sequences emerge after reorganization of network correlation structure during associative learning

Animals can learn causal relationships between pairs of stimuli separated in time and this ability depends on the hippocampus.Such learning is believed to emerge from alterations in network connectivity, but large-scale connectivity is difficult to measure directly, especially during learning.Here, we show that area CA1 cells converge to time-locke

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